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Related Experiment Video

Updated: Jan 30, 2026

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Published on: November 14, 2016

Claudin-5: gatekeeper of neurological function.

Chris Greene¹, Nicole Hanley¹, Matthew Campbell²

¹Trinity College Dublin, Smurfit Institute of Genetics, Dublin 2, Ireland.

Fluids and Barriers of the CNS

|January 30, 2019

Summary

Tight junction proteins, like claudin-5, maintain the blood-brain barrier (BBB). Regulating claudin-5 offers therapeutic potential for neurological and psychiatric disorders by restoring BBB integrity.

Keywords:

Blood–brain barrier Claudin-5 Endothelial cell Tight junction

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Lipidomics and Transcriptomics in Neurological Diseases

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Published on: March 18, 2022

Area of Science:

Neuroscience
Cell Biology
Pharmacology

Background:

The blood-brain barrier (BBB) protects the central nervous system (CNS) via tight junctions between endothelial cells.
Tight junctions restrict paracellular diffusion, crucial for neural homeostasis.
This barrier limits drug delivery to the CNS, with over 95% of small molecules unable to penetrate.

Purpose of the Study:

To review the role of tight junction proteins in BBB integrity.
To focus on claudin-5's function in homeostatic and pathological conditions.
To summarize therapeutic strategies targeting tight junctions for CNS disorders.

Main Methods:

Literature review of studies on blood-brain barrier tight junctions.
Analysis of claudin-5's role in neurological, neuroinflammatory, and psychiatric disorders.
Synthesis of therapeutic approaches targeting tight junction protein complexes.

Main Results:

Claudin-5 is the most abundant tight junction protein at the BBB.
Claudin-5 dysfunction is linked to Alzheimer's disease, multiple sclerosis, depression, and schizophrenia.
Modulating claudin-5 levels can potentially alleviate symptoms in these disorders.

Conclusions:

Tight junction proteins, particularly claudin-5, are critical for BBB integrity and neural homeostasis.
Claudin-5 dysregulation is implicated in various CNS diseases.
Targeting tight junction complexes presents a promising therapeutic avenue for CNS disorders.