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Chronic Basophilic Leukaemia in a Dog
D Azakami1, A Saito2, K Ochiai3
1Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Journal of Comparative Pathology
|January 30, 2019
Summary
This case study details a dog diagnosed with chronic basophilic leukemia, a rare cancer. The findings offer insights into the pathological features of this canine leukemia.
Area of Science:
- Veterinary Pathology
- Canine Hematology
- Neoplastic Disease
Background:
- A 13-year-old mixed-breed dog presented with chronic emaciation, inappetence, and vomiting.
- Initial bloodwork revealed leukocytosis, thrombocytosis, and anemia.
Observation:
- Necropsy showed red bone marrow, hepatomegaly, and splenomegaly.
- Bone marrow smears and histology confirmed a high proportion of neoplastic basophilic lineage cells.
- Immunohistochemistry identified neoplastic basophils positive for vimentin and myeloperoxidase.
Findings:
- The study diagnosed chronic basophilic leukemia based on clinicopathological and histopathological findings.
- Neoplastic basophils infiltrated the bone marrow, liver, and spleen.
- Specific immunohistochemical markers aided in characterizing the neoplastic cells.
Implications:
- This case provides valuable insights into the pathological presentation of chronic basophilic leukemia in dogs.
- Understanding these features can aid in earlier diagnosis and treatment strategies for canine leukemia.
- Further research into canine hematologic malignancies is warranted.
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