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Published on: September 19, 2019
Assisted conception does not increase the risk for mother-to-child transmission of hepatitis B virus, compared with
Rui Nie1, Mingyue Wang1, Tantan Liao2
1Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Objective:
To determine whether assisted conception increases the risk for mother-to-child transmission of hepatitis B virus (HBV) infection compared with natural conception.
Design:
Prospective cohort study.
Setting:
Research laboratory.
Patient(S):
A total of 305 children, 176 born with assisted conception and 129 born with natural conception, were born to a total of 251 hepatitis B surface antigen- (HBsAg-) positive women.
Intervention(S):
None.
Main Outcome Measure(S):
The seropositive rates of HBsAg in children at birth and HBV infection rates at 9-15 months of age.
Result(S):
Overall, 7.5% (23/305) of children were HBsAg-positive at birth. The rate of HBsAg-positive children at birth did not significantly differ between children in the assisted conception group compared with those in the natural conception group (6.3% [11/176] vs. 9.3% [12/129]). Multivariate logistic regression analysis showed that conception method is not related to the rate of HBsAg-positive children at birth. All children who were positive for HBsAg at birth and were followed up for 9-15 months became negative for HBsAg after hepatitis B immunization.
Conclusion(S):
Assisted conception does not increase the risk for mother-to-child transmission of HBV compared with natural conception.
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