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Exploiting epigenetically mediated changes: Acute myeloid leukemia, leukemia stem cells and the bone marrow

Aksinija A Kogan1, Rena G Lapidus2, Maria R Baer2

  • 1Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, United States; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, United States.

Advances in Cancer Research
|January 30, 2019
PubMed
Summary

This review explores how the bone marrow microenvironment (BME) supports acute myeloid leukemia (AML) stem cells. Epigenetic changes in AML and the BME may be targeted by demethylating agents to re-sensitize leukemia cells to treatment.

Keywords:
Acute myeloid leukemiaEpigeneticsLeukemia stem cellsMicroenvironment

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