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The Exposome and Asthma.
Ahila Subramanian1, Sumita B Khatri2
1Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, CWRU School of Medicine, 9500 Euclid Avenue/A90, Cleveland, OH 4419, USA.
Clinics in Chest Medicine
|January 30, 2019
Summary
The exposome, encompassing environmental exposures throughout life, interacts with genetic susceptibility to influence asthma development. Understanding these environmental factors is crucial for effective asthma management and advocacy.
Area of Science:
- Environmental Health
- Epidemiology
- Genetics
Background:
- Asthma pathogenesis is influenced by complex interactions between individuals and their environments.
- Both indoor and outdoor environmental exposures contribute to disease development.
- Genetic susceptibility plays a key role in asthma initiation and progression.
Purpose of the Study:
- To highlight the significance of the exposome in asthma.
- To emphasize the interplay between environmental factors and host genetics in asthma.
- To underscore the need for awareness of global environmental changes for health professionals.
Main Methods:
- Literature review on exposome and asthma.
- Analysis of environmental exposure data.
- Consideration of genetic predisposition in asthma.
Main Results:
- Environmental exposures, varying in level and duration, are implicated in asthma.
- The exposome significantly modifies the impact of genetic susceptibility on asthma.
- Global environmental changes present challenges for asthma management.
Conclusions:
- A comprehensive understanding of the exposome is vital for addressing asthma.
- Integrating environmental and genetic information is key to personalized asthma care.
- Health professionals must be informed about environmental exposures to advocate effectively.
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