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Effects of MMP-1 1G/2G polymorphism on osteoarthritis: A meta-analysis study

Bo Xu1, Run-Lin Xing2, Li Zhang2

  • 1The Affiliated Hospital of Nanjing University of TCM, Jiangsu Province Hospital of TCM, Nanjing, PR China; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, PR China.

Acta Orthopaedica Et Traumatologica Turcica
|January 30, 2019
PubMed
Abstract

Insights

The Matrix metalloproteinase 1 (MMP-1) -1607 1G/2G polymorphism does not appear to increase osteoarthritis risk overall. However, this genetic variant may be associated with increased OA susceptibility in individuals younger than 60 years.

Area of Science:

  • Genetics
  • Rheumatology
  • Biochemistry

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease.
  • Genetic factors play a role in OA pathogenesis.
  • The Matrix metalloproteinase 1 (MMP-1) gene, specifically the -1607 1G/2G polymorphism (rs1799750), has been investigated for its association with OA risk.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the association between the MMP-1 -1607 1G/2G polymorphism and the risk of developing osteoarthritis.
  • To evaluate the overall and subgroup associations of this genetic variant with OA.

Main Methods:

  • A systematic literature search was performed across major databases including Web of Science, Embase, and PubMed.
  • Studies investigating the MMP-1 -1607 1G/2G polymorphism and OA risk were included.
  • Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association.

Main Results:

  • Overall, no statistically significant association was found between the MMP-1 -1607 1G/2G polymorphism and osteoarthritis risk across various genetic models.
  • Subgroup analysis revealed a significant association in individuals younger than 60 years, suggesting increased OA susceptibility in this demographic.
  • Specific ORs and P-values indicated significant findings in younger populations for different genotype comparisons.

Conclusions:

  • The MMP-1 -1607 1G/2G polymorphism may be linked to an increased susceptibility to osteoarthritis, particularly in younger individuals (under 60 years).
  • Further research with more detailed data is recommended to validate these findings and elucidate the underlying mechanisms.
Keywords:
MMP-1Meta-analysisOsteoarthritisPolymorphismrs1799750

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