Related Experiment Video
Updated: Jan 30, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Impacts of Brexit on fruit and vegetable intake and cardiovascular disease in England: a modelling study
Paraskevi Seferidi1, Anthony A Laverty1, Jonathan Pearson-Stuttard1,2
1Public Health Policy Evaluation Unit, School of Public Health, Imperial College London, London, UK.
Objectives:
To estimate the potential impacts of different Brexit trade policy scenarios on the price and intake of fruits and vegetables (F&V) and consequent cardiovascular disease (CVD) deaths in England between 2021 and 2030.
Design:
Economic and epidemiological modelling study with probabilistic sensitivity analysis.
Setting:
The model combined publicly available data on F&V trade, published estimates of UK-specific price elasticities, national survey data on F&V intake, estimates on the relationship between F&V intake and CVD from published meta-analyses and CVD mortality projections for 2021-2030.
Participants:
English adults aged 25 years and older.
Interventions:
We modelled four potential post-Brexit trade scenarios: (1) free trading agreement with the EU and maintaining half of non-EU free trade partners; (2) free trading agreement with the EU but no trade deal with any non-EU countries; (3) no-deal Brexit; and (4) liberalised trade regime that eliminates all import tariffs.
Outcome Measures:
Cumulative coronary heart disease and stroke deaths attributed to the different Brexit scenarios modelled between 2021 and 2030.
Results:
Under all Brexit scenarios modelled, prices of F&V would increase, especially for those highly dependent on imports. This would decrease intake of F&V between 2.5% (95% uncertainty interval: 1.9% to 3.1%) and 11.4% (9.5% to 14.2%) under the different scenarios. Our model suggests that a no-deal Brexit scenario would be the most harmful, generating approximately 12 400 (6690 to 23 390) extra CVD deaths between 2021 and 2030, whereas establishing a free trading agreement with the EU would have a lower impact on mortality, contributing approximately 5740 (2860 to 11 910) extra CVD deaths.
Conclusions:
Trade policy under all modelled Brexit scenarios could increase price and decrease intake of F&V, generating substantial additional CVD mortality in England. The UK government should consider the population health implications of Brexit trade policy options, including changes to food systems.
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