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Updated: Jan 30, 2026

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
Published on: March 18, 2014
[A Case of a Malignant Phyllodes Tumor That Was Difficult to Distinguish from Stromal Sarcoma]
Wataru Goto1, Shinichiro Kashiwagi, Koji Takada
1Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.
Abstract:
A 72-year-old woman visited our hospital with the chief complaint of a mass in the right breast. Breast ultrasonography revealed a hypoechoic area with a distinct border in the right breast. A core needle biopsy showed the proliferation of spindle cells in the stroma, and she was diagnosed with stromal sarcoma or malignant phyllodes tumor. Right lumpectomy was performed. Pathological examination revealed a malignant phyllodes tumor with a sarcomatous lesion. Although she did not receive adjuvant chemotherapy, she is alive without any recurrence 2 years after the surgery. It is difficult to distinguish phyllodes tumors from stromal sarcoma, based on core needle biopsy, and the prognosis of malignant phyllodes tumors with distant metastases is poor. Rapid surgery to determine an accurate diagnosis and careful follow-up after surgery are impor- tant.
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