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Updated: Jan 30, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Naturally clonal vertebrates are an untapped resource in ecology and evolution research
Kate L Laskowski1, Carolina Doran2, David Bierbach2
1Department of Biology & Ecology of Fishes, Leibniz-Institute of Freshwater Ecology & Inland Fisheries, Berlin, Germany. laskowski@igb-berlin.de.
Abstract:
Science requires replication. The development of many cloned or isogenic model organisms is a testament to this. But researchers are reluctant to use these traditional animal model systems for certain questions in evolution or ecology research, because of concerns over relevance or inbreeding. It has largely been overlooked that there are a substantial number of vertebrate species that reproduce clonally in nature. Here we highlight how use of these naturally evolved, phenotypically complex animals can push the boundaries of traditional experimental design and contribute to answering fundamental questions in the fields of ecology and evolution.
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