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Propranolol: A 50-Year Historical Perspective.

A V Srinivasan1

  • 1Former Professor of Neurology and Head - Institute of Neurology, Madras Medical College, Chennai, Emeritus Professor - The Tamil Nadu Dr. M.G.R. Medical University, Adjunct Professor - Indian Institute of Technology (IIT - Chennai), Tamil Nadu, India.

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|January 30, 2019
PubMed
Summary
This summary is machine-generated.

Propranolol, a beta-adrenergic receptor antagonist, has evolved from treating angina to managing diverse conditions like hypertension and anxiety. Its enduring efficacy and cost-effectiveness continue to drive new therapeutic discoveries.

Keywords:
Anxietybeta-blockermyocardial infarctionportal hypertensionpropranolol

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Area of Science:

  • Pharmacology
  • Cardiology
  • Neurology

Background:

  • Propranolol, a beta-adrenergic receptor antagonist, was developed over 50 years ago.
  • Initially for angina pectoris, its therapeutic applications have significantly expanded.
  • It is recognized for its cost-effectiveness compared to alternative treatments.

Purpose of the Study:

  • To review the historical development and therapeutic journey of propranolol.
  • To highlight the diverse range of cardiovascular and noncardiovascular conditions treated by propranolol.
  • To emphasize the ongoing discovery of new indications for this established drug.

Main Methods:

  • Literature review of propranolol's development and clinical applications.
  • Analysis of its pharmacological actions and receptor interactions.
  • Examination of its efficacy across various medical conditions.

Main Results:

  • Propranolol is effective in treating hypertension, cardiac arrhythmias, myocardial infarction, migraine, portal hypertension, anxiety, essential tremors, hyperthyroidism, and pheochromocytoma.
  • Its central and peripheral effects contribute to its broad utility.
  • Newer indications for propranolol are still being identified.

Conclusions:

  • Propranolol remains a vital medication with a wide spectrum of therapeutic uses.
  • Its journey from angina treatment to diverse applications showcases its pharmacological versatility.
  • The drug's continued relevance is supported by ongoing research and its cost-effectiveness.