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Sleep Duration and Diabetic Kidney Disease
Nicholas Y Q Tan1, Joel Chan1, Ching-Yu Cheng1,2,3
1Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Frontiers in Endocrinology
|January 30, 2019
Summary
Both very short and long sleep durations are linked to diabetic kidney disease (DKD) risk. This includes reduced kidney function (eGFR) and albuminuria in Asian adults with diabetes.
Area of Science:
- Nephrology
- Endocrinology
- Sleep Medicine
Background:
- Sleep duration is a potential risk factor for diabetes and its complications.
- The specific relationship between sleep duration and diabetic kidney disease (DKD) remains unclear.
Purpose of the Study:
- To investigate the association between sleep duration and DKD in two Asian populations.
- To examine how different sleep durations correlate with reduced estimated glomerular filtration rate (eGFR) and albuminuria.
Main Methods:
- A cross-sectional study of 1,258 diabetic adults (Malay and Indian) aged 40-80 years in Singapore.
- DKD was defined by low eGFR (<60 mL/min/1.73 m²) and albuminuria (in Indian participants).
- Sleep duration was self-reported and categorized (very short <5h, short 5-6.9h, normal 7-8h, long >8h); analyses adjusted for confounders.
Main Results:
- Long sleep duration was associated with higher odds of renal insufficiency (low eGFR) compared to normal sleep duration (OR: 2.31 [1.27-4.19]).
- Both long and very short sleep durations were linked to higher odds of albuminuria in Indian participants (ORs: 2.44 [1.36, 4.38] and 2.37 [1.25, 4.50], respectively).
Conclusions:
- Abnormally short or long sleep durations are associated with diabetic kidney disease (DKD).
- These associations manifest as reduced eGFR or increased albuminuria.
- Further longitudinal studies are needed to confirm these findings.
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