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Current and Emerging Targets in Immunotherapy for Osteosarcoma

Shinji Miwa1, Toshiharu Shirai1,2, Norio Yamamoto1

  • 1Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa 920-8640, Japan.

Journal of Oncology
|January 30, 2019
PubMed

Insights

Immunotherapy shows promise for osteosarcoma treatment, especially for metastatic or unresectable cases. This review explores various immunotherapies and their potential as adjuvant treatments to improve patient outcomes.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Osteosarcoma is the most common primary bone cancer.
  • Current chemotherapy outcomes for metastatic or unresectable osteosarcoma remain unsatisfactory.
  • Novel systemic therapies are crucial for improving patient survival rates.

Purpose of the Study:

  • To provide an overview of diverse immunotherapies for osteosarcoma.
  • To discuss the potential of immunotherapy as an adjuvant treatment for osteosarcoma.
  • To highlight the promise of immunotherapy in managing osteosarcoma.

Main Methods:

  • Review of existing literature on immunotherapies used in malignancies.
  • Analysis of studies involving immune modulators, dendritic cells, immune checkpoint inhibitors, and engineered T cells.
  • Exploration of historical and recent applications of immunotherapy in osteosarcoma.

Main Results:

  • Immunotherapy has been utilized in osteosarcoma treatment with some documented patient responses.
  • Various immunotherapeutic approaches, including immune modulators and cell-based therapies, are being investigated.
  • Despite limited reports, immunotherapy is recognized as a promising therapeutic avenue.

Conclusions:

  • Immunotherapy represents a significant and promising treatment modality for osteosarcoma.
  • Further research into immunotherapy applications could lead to improved outcomes for osteosarcoma patients.
  • Immunotherapy holds potential as an effective adjuvant therapy to complement existing treatments.

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