Related Experiment Video

Updated: Jan 30, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

4.0K

Cutaneous Side Effects of Targeted Therapy and Immunotherapy for Advanced Melanoma

Irene Russo1, Ludovica Zorzetto1, Vanna Chiarion Sileni2

  • 1Unit of Dermatology, University of Padua, Via Gallucci 4, 35128 Padova, Italy.

Scientifica
|January 30, 2019
PubMed

Insights

Targeted and immune therapies for advanced melanoma can cause skin side effects. This review covers their presentation, mechanisms, and management, focusing on BRAF/MEK and immune-checkpoint inhibitors.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Melanoma incidence is rising globally, necessitating advanced treatments.
  • Recent advances in understanding melanoma pathogenesis have led to new targeted and immunotherapies.
  • Cutaneous side effects are common with these advanced melanoma treatments.

Purpose of the Study:

  • To review the clinical presentation, mechanisms, and management of side effects from advanced melanoma therapies.
  • To discuss side effects associated with BRAF/MEK inhibitors.
  • To cover side effects related to immune-checkpoint inhibitors, including CTLA-4 and PD-1 inhibitors.

Main Methods:

  • Literature review of clinical presentations.
  • Review of pathomechanisms of treatment-related side effects.
  • Compilation of management strategies for cutaneous adverse events.

Main Results:

  • Targeted therapies (BRAF/MEK inhibitors) and immunotherapies (CTLA-4, PD-1 inhibitors) are associated with specific cutaneous side effects.
  • Understanding the mechanisms aids in predicting and managing these adverse events.
  • Effective management strategies can mitigate treatment toxicity and improve patient outcomes.

Conclusions:

  • Cutaneous side effects are a significant clinical consideration in advanced melanoma treatment.
  • Proactive identification and management of these side effects are crucial for patient care.
  • Further research into optimizing treatment tolerability is warranted.

More Related Videos

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

954
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.9K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.9K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.8K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
Group Therapy01:26

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
429