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Correlation of hepatorenal dysfunction in pediatric malaria

Niranjan Nagaraj1, Pramod Kumar Berwal1, Anusha Srinivas2

  • 1Department of Paediatrics, SP Medical College, Bikaner, Rajasthan, India.

Tropical Parasitology
|January 30, 2019
PubMed

Insights

This study investigated hepatorenal dysfunction in pediatric malaria patients. A significant association was found between high bilirubin levels and renal failure in Plasmodium falciparum and mixed malaria infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Hepatology
  • Nephrology

Background:

  • Malaria remains a globally prevalent infectious disease.
  • Hepatorenal dysfunction is a critical complication in pediatric malaria cases.

Purpose of the Study:

  • To assess the correlation between hepatorenal dysfunction and malaria in children.
  • To raise awareness about early malaria complications.

Main Methods:

  • Study conducted on pediatric malaria patients admitted to PBM hospital, Bikaner (2011-2012).
  • Malaria diagnosis confirmed via blood smear/optimal test.
  • Inclusion of patients with malarial hepatic and renal dysfunction.

Main Results:

  • Mean age of affected children was 5-10 years, with a male preponderance.
  • Significant association between elevated serum bilirubin (>3 mg/dl) and renal failure in Plasmodium falciparum (40.9%) and mixed infections (71.43%).
  • No significant association observed in Plasmodium vivax infections (10.52%).

Conclusions:

  • Early detection and management of hepatorenal dysfunction are crucial in pediatric malaria.
  • Findings highlight the need for prompt action to prevent severe malaria complications.
Abstract

Keywords:
Bikanerblood smearhepatorenalmalariaoptimal

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