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Updated: Jan 30, 2026

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
Published on: August 22, 2025
CD73; a key ectonucleotidase in the development of breast cancer: Recent advances and perspectives
Anvar Soleimani1,2, Eskandar Taghizadeh3,2, Shirin Shahsavari4
1Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Iran.
Abstract:
Tumor cell invasion and metastasis are the definitive cause of mortality in breast cancer (BC). Hypoxia and pro-inflammatory cytokines upregulate the CD73 gene in the tumor microenvironment. Subsequently, CD73 triggers molecular and cellular signaling pathways by both enzymatic and nonenzymatic pathways, which finally leads to breast tumor progression and development. In this paper, we summarize current advances in the understanding of CD73-driven mechanisms that promote BC development and mortality. Furthermore, we evaluate the therapeutic potential of CD73 targeting in BC.
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