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miR-9: From function to therapeutic potential in cancer
Mostafa Khafaei1, Ehsan Rezaie2, Ali Mohammadi1
1Human Genetics Research Center, Baqiyatallah Medical Science University, Tehran, Iran.
Journal of Cellular Physiology
|January 30, 2019
Summary
Circular microRNAs (miRNAs) are vital biomarkers for cancer prognosis. This study reviews the role of miR-9, a microRNA, as a prognostic marker in various human tumors, offering insights for novel cancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Biomarkers
Background:
- Malignant neoplasms are a leading global cause of death, presenting challenges in diagnosis, remission classification, and treatment forecasting.
- MicroRNAs (miRNAs) play crucial roles in cellular processes and cancer development, making them promising minimally invasive biomarkers.
- Aberrant expression of specific miRNAs, including miR-9, is frequently observed in various cancers, suggesting their involvement in tumorigenesis and prognosis.
Purpose of the Study:
- To investigate the precise role of miR-9 in patients with malignant neoplasms.
- To clarify the overall role of miR-9 as a prognostic marker in several human tumors through a comprehensive review of existing studies.
Main Methods:
- Systematic review and analysis of existing research studies.
- Examination of data on miR-9 expression levels and its association with cancer prognosis.
- Investigation of miR-9's influence on different genes and its dual role in various cancer types.
Main Results:
- miR-9 exhibits varied functions in different tissues and cancer types, influencing diverse target genes.
- Aberrant levels of miR-9 are consistently observed across a spectrum of human malignancies.
- The expression of miR-9 is associated with the prognosis of various carcinomas, highlighting its potential as a prognostic marker.
Conclusions:
- miR-9 plays a complex and context-dependent role in human cancers.
- miR-9 holds significant potential as a prognostic biomarker for various tumors.
- Further research into miR-9 could pave the way for novel therapeutic strategies in cancer treatment.
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