Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Oxygen radicals in septic shock].

M H Schoenberg1, H G Beger

  • 1Abteilung für Allgemeine Chirurgie, Chirurgische Universitätsklinik Ulm/Donau.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum amyloid A versus C-reactive protein in acute pancreatitis: clinical value of an alternative acute-phase reactant.

Critical care medicine·2001
Same author

Sphincter-saving treatment in epidermoid anal cancer: cooperative analysis of 142 patients in five German university surgical centers.

International journal of colorectal disease·2001
Same author

Follow-up in colorectal cancer: cost-effectiveness analysis of established and novel concepts.

Langenbeck's archives of surgery·2000
Same author

Fluorescence detection of small gastrointestinal tumours: principles, technique, first clinical experience.

Langenbeck's archives of surgery·2000
Same author

Prospective comparison of endoscopic ultrasound and endoscopic retrograde cholangiopancreatography in the preoperative assessment of masses in the pancreatic head.

Digestive surgery·2000
Same author

Oxaliplatin exerts potent in vitro cytotoxicity in colorectal and pancreatic cancer cell lines and liver metastases.

Anticancer research·2000

In septic shock, oxygen free radicals contribute to organ damage. Administering free radical scavengers, with or without antibiotics, reduced tissue damage and improved survival rates in animal models.

Area of Science:

  • Biochemistry
  • Pathophysiology
  • Pharmacology

Context:

  • Sepsis involves complex physiological changes, including polymorphonuclear granulocyte (PMN) activation.
  • Increased prostaglandin metabolism and tissue hypoxia are key features of septic shock.
  • Septic shock leads to heightened production of oxygen free radicals and their metabolites.

Purpose:

  • To investigate the role of oxygen free radicals in sepsis-induced organ damage.
  • To evaluate the efficacy of free radical scavengers in mitigating septic shock consequences.
  • To assess the combined effect of free radical scavengers and antibiotics on survival rates.

Summary:

  • Septic shock is characterized by increased generation of oxygen free radicals, linked to shock organ damage.

Related Experiment Videos

  • Animal studies demonstrated that free radical scavengers, alone or with antibiotics, attenuated tissue damage.
  • Treatment with free radical scavengers significantly improved survival rates in animal models of septic shock.

    • Impact:

    • Findings suggest free radical scavenging as a potential therapeutic strategy for sepsis.
    • Highlights the critical role of oxidative stress in sepsis pathogenesis.
    • Provides evidence for improved outcomes in septic shock management through antioxidant interventions.