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Updated: Jan 30, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
[Progress on cancer associated fibroblasts in tumor immunoregulation]
Gaopeng Li1, Jia He1, Qingqing Wang1
1Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Abstract:
Cancer associated fibroblasts (CAFs) are important components of the tumor microenvironment. Through secreting of multiple growth factors, cytokines and proteases, CAFs play a significant role in regulating the recruitment and function of various innate immune cells and adaptive immune cells in tumor microenvironment. In addition, extracellular matrix secreted by CAFs can also promote the formation of immunosuppression and hypoxia of tumor microenvironment. Here, we review the progress on CAFs in regulation of immune cells and tumor immunity.
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