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Updated: Jan 30, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
Radiosensitivity nomogram based on circulating neutrophils in thoracic cancer
Pingping Hu1, Qiqi Liu2,3, Guodong Deng4
1Department of Radiation Oncology, Qianfoshan Hospital affiliated to Shandong University, Shandong University, 16766 Jingshi Road, Jinan, 250014, PR China.
Aim:
To evaluate the prediction ability of neutrophils and develop a nomogram on radiosensitivity in thoracic cancer patients.
Methods:
We retrospectively reviewed 398 lung and esophageal cancers patients who received external-beam radiotherapy or concurrent chemoradiotherapy as first-line therapy.
Results:
Logistic regression model showed that patients with low levels of neutrophil counts and/or TGF-β1 exhibited better radiation sensitivity. Furthermore, a nomogram was created to predict radiotherapy sensitivity. The combination of neutrophil count and TGF-β1 level was an independent prognostic factor for lung and esophageal cancers patients.
Conclusion:
The study developed a nomogram based on the levels of circulating neutrophils and TGF-β1. The prediction value in radiosensitivity and protumorigenic effect of neutrophils might owe to N2 tumor-associated neutrophils.
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