The chemical constituents with cytotoxicity from Urtica fissa seed
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Published on: February 2, 2024
Hao Zhang1, Ying Zhang1, Meng-Yue Wang1
1School of Pharmacy, Shanghai Jiao Tong University , Shanghai 200240 , China.
Abstract:
Phytochemical investigation of Urtica fissa seed led to the isolation of a new secolignan (1) and a new glycoalkaloid (2), together with 16 known compounds (3-18). The subsequent active evaluation indicated that two lignans (1, 12), two ceramides (3, 4), and the glycoalkaloid (2) possessed the significant cytotoxicity. They could obviously inhibit the proliferation of tumor cells HeLa and CCRF-CEM cells, with IC50 values as low as 1.5 μM.
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