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Updated: Jan 30, 2026

Multifactorial Assessment of Motor Behavior in Rats after Unilateral Sciatic Nerve Crush Injury
Published on: July 31, 2021
Screening of NogoA/NTR-related differential genes in rat sciatic nerve injury signal pathway
Junjie Jiang1, Zhiwu Zhang1, Yuanchen Yu1
1Department of Hand Surgery, Yantaishan Hospital, Yantai, PR China.
Aim:
To screen the differential genes in NogoA/NTR-related pathways that associate with sciatic nerve injury.
Results:
There was no difference in the expression of NogoA, NTR and Ntrk2. Differential genes existed in 11 differential pathways that include NogoA, NTR and Ntrk2. Pathways closely related to sciatic nerve injury are MAPK, endophagocytosis, apoptosis, neurotrophin signaling and inflammatory mediators. NTRK1, FASLG, LDLR ADRB1 and HTR2A in model rats were downregulated compared with control rats, IL1R1, CSF1R, BCL2L1 and HRH1 in model rats were upregulated compared with control rats.
Conclusion:
MAPK, endophagocytic, apoptotic, neurotrophic factor and inflammatory mediators of ductal mediators may be involved in the sciatic nerve injury in rats. The differentially expressed genes in these pathways may play important roles in sciatic nerve injury.
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