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Intestinal microbiota predicts lung cancer patients at risk of immune-related diarrhea
Tian Liu1, Qi Xiong1, Lingling Li1
1Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China, 100853.
Aim:
Previous studies showed that some patients after the treatment of anti-programmed cell death protein-1 (anti-PD-1) antibodies experienced immune-related diarrhea. In this study, we aim to explore the association between intestinal microbiota and immune-related diarrhea.
Methods:
We obtained the fecal samples of 26 advanced lung cancer patients before the first dose of anti-PD-1 antibodies.
Results:
Eight of 26 patients experienced diarrhea after the treatment of anti-PD-1 antibodies. At the phylum level, our study demonstrated that Bacteroidetes were higher in diarrhea-free (D-F) patients, while Firmicutes were lower. Bacteroides and Parabacteroides belonging to Bacteroidetes phylum and Phascolarctobacterium of Firmicutes phylum were more abundant in D-F patients. Whereas, Veillonella of Proteobacteria phylum was lower in D-F patients.
Conclusion:
Our study highlights that intestinal microbiota variation is correlated with the subsequent development of immune-related diarrhea.
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