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Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
Published on: November 28, 2016
Human T lymphotropic virus type 1 and risk of cardiovascular disease: High-density lipoprotein dysfunction versus
Sara Samadi1,2,3, Samaneh Abolbashari1,2, Zahra Meshkat1
1Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
Human T lymphotropic virus type 1 (HTLV1) infection is linked to higher levels of HDL lipid peroxidation (HDLox), a marker of HDL dysfunction and cardiovascular disease risk. This finding suggests HTLV1 may increase CVD risk through impaired HDL function.
Area of Science:
- Cardiovascular Disease Research
- Infectious Diseases
- Lipid Metabolism
Background:
- High-density lipoprotein (HDL) is recognized for its protective role against cardiovascular disease (CVD).
- HDL dysfunction, indicated by HDL lipid peroxidation (HDLox), is increasingly implicated as a CVD risk factor.
- The relationship between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk remains largely unexplored.
Purpose of the Study:
- To investigate the association between HTLV1 infection and HDL dysfunction, using HDLox as a biomarker.
- To assess whether HTLV1 infection is linked to traditional cardiovascular disease risk factors.
Main Methods:
- A subgroup of the MASHAD cohort study was analyzed, including 50 HTLV1-positive and 112 HTLV1-negative individuals.
- Serum HDLox levels were measured, alongside traditional cardiovascular disease risk factors (hs-CRP, lipid profile, fasting blood glucose).
- Multivariate analyses and logistic regression were employed to determine the association between HTLV1 infection and HDLox.
Main Results:
- No association was found between HTLV1 infection and traditional CVD risk factors, including HDL-C.
- Serum HDLox was independently associated with HTLV1 infection.
- HTLV1-positive subjects exhibited significantly higher HDLox levels (OR 9.35, P < 0.001), with an approximate 20% increase compared to uninfected individuals.
Conclusions:
- Serum HDLox is elevated in individuals with HTLV1 infection.
- HTLV1 infection is associated with HDL dysfunction, suggesting a potential mechanism for increased cardiovascular disease risk.
Abstract:
High-density lipoprotein (HDL) is thought to be protective against cardiovascular disease (CVD), and HDL dysfunction is considered to be a risk factor for CVD. It is unclear whether there is an association between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk. We have assessed HDL lipid peroxidation (HDLox) as a marker of HDL dysfunction and CVD risk in a subgroup of the MASHAD cohort study. One hundred and sixty two individuals including 50 subjects positive for HTLV1 infection and 112 individuals negative for HTLV1 infection were recruited. Anthropometric and biochemical parameters including serum hs-CRP, fasted lipid profile (HDL-C, LDL, triglycerides, and cholesterol), and fasting blood glucose were determined. Serum HDLox was also measured in the study participants. Multivariate analyses were used to evaluate the association between serum HDLox and HTLV1 infection. None of the traditional CVD risk factors were associated with HTLV1 infection, including serum HDL-C. However, serum HDLox was independently associated with the presence of HTLV1 infection. Logistic regression analysis showed that subjects who were positive for HTLV1 infection were also significantly more likely than uninfected individuals to have higher HDLox (odds ratio 9.35, 95%CI: 3.5-24.7; P < 0.001). HDLox was increased approximately 20% (P < 0.001) in infected subjects compared to the uninfected group. Serum HDLox is a marker of CVD risk factor and increased in individuals affected by HTLV1 infection compared to healthy subjects. © 2019 BioFactors, 45(3):374-380, 2019.
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