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Updated: Jan 30, 2026
Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
Evaluation of the distribution and progression of intraluminal thrombus in abdominal aortic aneurysms using
Chengcheng Zhu1, Joseph R Leach1, Bing Tian2
1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, California, USA.
Background:
Intraluminal thrombus (ILT) signal intensity on MRI has been studied as a potential marker of abdominal aortic aneurysm (AAA) progression.
Purpose:
1) To characterize the relationship between ILT signal intensity and AAA diameter; 2) to evaluate ILT change over time; and 3) to assess the relationship between ILT features and AAA growth.
Study Type:
Prospective.
Subjects:
Eighty AAA patients were imaged, and a subset (n = 41) were followed with repeated MRI for 16 ± 9 months.
Field Strength/Sequence:
3D black-blood fast-spin-echo sequence at 3 T.
Assessment:
ILT was designated as "bright" if the signal was greater than 1.2 times that of adjacent psoas muscle. AAAs were divided into three groups based on ILT: Type 1: bright ILT; Type 2: isointense ILT; Type 3: no ILT. During follow-up, an active ILT change was defined as new ILT formation or an increase in ILT signal intensity to bright; stable ILT was defined as no change in ILT type or ILT became isointense from bright previously.
Statistical Tests:
Shapiro-Wilk test; Mann-Whitney U-test; Fisher's exact test; Kruskal-Wallis test; Spearman's r; intraclass correlation coefficient (ICC), Cohen's kappa.
Results:
AAAs with Type 1 ILT were larger than those with Types 2 and 3 ILT (5.1 ± 1.1 cm, 4.4 ± 0.9 cm, 4.2 ± 0.8 cm, P = 0.008). The growth rate of AAAs with Type 1 ILT was significantly greater than that of AAAs with Types 2 and 3 ILT (2.6 ± 2.5, 0.6 ± 1.3, 1.5 ± 0.6 mm/year, P = 0.01). During follow-up, AAAs with active ILT changes had a 3-fold increased growth rate compared with AAAs with stable ILT (3.6 ± 3.0 mm/year vs. 1.2 ± 1.5 mm/year, P = 0.008).
Data Conclusion:
AAAs with bright ILT are larger in diameter and grow faster. Active ILT change is associated with faster AAA growth. Black-blood MRI can characterize ILT features and monitor their change over time, which may provide new insights into AAA risk assessment.
Level Of Evidence:
2 Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019;50:994-1001.
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