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Oral etoposide.

N C Phillips1

  • 1Department of Medicine, Fox Chase Cancer Center, Philadelphia, PA 19111.

Drug Intelligence & Clinical Pharmacy
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Oral etoposide offers an effective and cost-efficient treatment for small cell lung cancer (SCLC). Pharmacokinetic studies show similar absorption to intravenous etoposide, supporting its use as an outpatient alternative.

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Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Etoposide, a podophyllotoxin derivative, is a chemotherapy agent used for various cancers, including small cell lung cancer (SCLC).
  • Intravenous etoposide has been a standard treatment for SCLC, with oral formulations now also available and approved for SCLC treatment.

Purpose of the Study:

  • To evaluate the efficacy and pharmacokinetics of oral etoposide compared to intravenous administration for small cell lung cancer (SCLC).

Main Methods:

  • Review of pharmacokinetic studies comparing oral and intravenous etoposide administration.
  • Analysis of bioavailability and other pharmacokinetic parameters.

Main Results:

  • Oral etoposide demonstrates a mean bioavailability of 50%, with significant inter-patient variability.

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  • Pharmacokinetic profiles are comparable between oral and intravenous routes.
  • Recommended oral dose is double the intravenous dose.

    • Conclusions:

    • Oral etoposide is an effective treatment for SCLC.
    • It provides a cost-effective and convenient outpatient option for SCLC patients.
    • Further clinical trials comparing administration routes are warranted.