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Body Temperature01:25

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The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
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Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
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A Foreign Body Response-on-a-Chip Platform.

Fatemeh Sharifi1,2, Su Su Htwe3, Martina Righi1

  • 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.

Advanced Healthcare Materials
|January 30, 2019
PubMed
Summary
This summary is machine-generated.

A new microfluidic chip models the foreign body response (FBR) to implants, simulating immune cell interactions and inflammation. This platform enables personalized FBR monitoring and testing of biomaterials and implants.

Keywords:
biomaterialsforeign body responsesimmune responsesimplantsorgans-on-a-chip

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Microfluidics

Background:

  • The foreign body response (FBR) is a major challenge for implantable devices and biomaterials.
  • Developing strategies to modulate FBR is crucial for improving implant success.
  • Current models often fail to fully replicate the complex in vivo microenvironment.

Purpose of the Study:

  • To develop a microfluidic platform, the FBR-on-a-chip (FBROC), for modeling the immune cell response to implants.
  • To mimic the native implant microenvironment, including tissue-vasculature interfaces and circulating immune cells.
  • To enable physiologically relevant and individual-specific interrogation of FBR.

Main Methods:

  • Development of a microfluidic platform (FBROC) to model implant-tissue-vasculature interactions.
  • Incorporation of extracellular matrix (ECM)-like hydrogels to simulate the tissue microenvironment.
  • Utilizing patient-derived peripheral blood mononuclear cells to assess inter-patient variability in FBR.

Main Results:

  • The FBROC platform successfully models the cascade of immune cell events during FBR.
  • Demonstrated that cytokine release (e.g., MCP-1) from hydrogels induces monocyte migration, mimicking inflammation.
  • Revealed significant inter-patient differences in FBR using patient-derived cells.

Conclusions:

  • The FBROC platform provides a novel and physiologically relevant tool for studying FBR.
  • This platform can be used to test various implants, including biomaterials and engineered tissues.
  • FBROC enables personalized monitoring and modulation strategies for FBR.