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Prevalence of coeliac disease in diabetic children and adolescents. A multicentre study

S Koletzko1, A Bürgin-Wolff, B Koletzko

  • 1Kinderklinik der Universität, Düsseldorf, Federal Republic of Germany.

European Journal of Pediatrics
|November 1, 1988
PubMed

Insights

Screening for coeliac disease (CD) in diabetic children using antigliadin antibodies (AGA) revealed a 1.1-1.3% prevalence. Early diabetes duration increased false-positive AGA results, impacting diagnostic specificity.

Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Immunology

Background:

  • Type 1 diabetes and coeliac disease (CD) are autoimmune conditions that can co-occur.
  • Screening for CD in diabetic populations is crucial for early diagnosis and management.

Purpose of the Study:

  • To determine the prevalence of coeliac disease (CD) in a cohort of diabetic children and adolescents.
  • To evaluate the utility of serum antigliadin antibodies (AGA) for screening CD in this population.

Main Methods:

  • Serum antigliadin antibodies (AGA) screening was conducted in 1032 diabetic children and adolescents.
  • Follow-up testing and jejunal biopsies were performed for positive AGA cases.
  • Diabetes duration and age at manifestation were analyzed in relation to CD diagnosis.

Main Results:

  • An estimated 1.1-1.3% prevalence of CD was found in Swiss and German diabetic children.
  • False-positive AGA titres were more frequent in patients with diabetes duration less than 1 year.
  • Children with both diabetes and CD presented with earlier diabetes onset but later CD diagnosis.

Conclusions:

  • AGA screening is a valuable tool for coeliac disease (CD) detection in diabetic children, with optimal specificity after one year of diabetes.
  • Co-occurrence of diabetes and CD impacts age of disease manifestation and diagnosis.
  • Further research is warranted to refine screening protocols and understand the interplay between these conditions.

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