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Intestinal Electrical Stimulation to Increase the Rate of Peristalsis

Genia Dubrovsky1, Yi-Kai Lo2, Po-Min Wang3

  • 1Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

The Journal of Surgical Research
|January 30, 2019
PubMed

Insights

Direct electrical stimulation significantly increased intestinal peristalsis in juvenile pigs, expelling more gel compared to no stimulation. This finding suggests electrical stimulation may treat pediatric gastrointestinal motility disorders.

Area of Science:

  • Gastroenterology
  • Medical Devices

Background:

  • Pediatric gastrointestinal motility disorders are a diverse group of conditions.
  • Electrical stimulation has shown promise in treating some of these disorders.

Purpose of the Study:

  • To investigate if direct electrical stimulation can enhance the rate of intestinal peristalsis.

Main Methods:

  • Juvenile mini-Yucatan pigs underwent anesthesia, and a jejunal segment was prepared.
  • Ultrasound gel expulsion via peristalsis was measured over 20-minute intervals, with and without direct electrical stimulation.

Main Results:

  • Intestinal electrical stimulation was confirmed to be effectively delivered.
  • An average of 1.57 g of gel was expelled during electrical stimulation, versus 0.40 g without (P < 0.01).

Conclusions:

  • Direct electrical stimulation accelerates the transit of gastrointestinal contents.
  • This method holds potential for treating various pediatric motility disorders.
Abstract

Keywords:
Electrical stimulationGastrointestinal motility disorderIntestinePeristalsis

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