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Is endocan a biochemical marker for asymptomatic target organ damage in hypertensive patients?

Mustafa Tarık Ağaç1, Behlül Kahyaoğlu, Muhammed Murat Necati Aksoy

  • 1Department of Cardiology, Faculty of Medicine, Sakarya University; Sakarya-Turkey. tarikagac@gmail.com.

Anatolian Journal of Cardiology
|January 30, 2019
PubMed

Insights

Endocan levels did not differ in asymptomatic hypertensive patients with or without target organ damage. This suggests endocan may not be a useful biomarker in early hypertension stages.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Biology

Background:

  • Asymptomatic target organ damage (AOD) is crucial for cardiovascular (CV) risk stratification in hypertension.
  • Endothelial dysfunction is a key factor in hypertension, and endocan is a novel marker.
  • Endocan levels are elevated in hypertensive patients with symptomatic CV and renal disease.

Purpose of the Study:

  • To investigate serum endocan levels in asymptomatic hypertensive patients with and without AOD.
  • To determine if endocan can serve as a biomarker for early-stage organ damage in hypertension.

Main Methods:

  • 132 asymptomatic hypertensive patients were studied.
  • 101 patients had at least one form of AOD.
  • Serum endocan levels were measured and compared between groups.

Main Results:

  • No significant difference in serum endocan levels was observed between hypertensive patients with and without AOD.
  • No correlation was found between endocan levels and various AOD-related continuous variables.
  • Specific AOD analysis also revealed no significant differences in endocan levels.

Conclusions:

  • Endocan may not be a reliable biomarker for detecting asymptomatic vascular damage in hypertension.
  • Its utility might be limited to indicating disease severity in advanced symptomatic stages.
  • Further research is needed to clarify endocan's role in early hypertensive vascular disease.
Abstract

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