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Updated: Jan 30, 2026
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Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
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Primary progressive aphasia: a model for neurodegenerative disease
Boon Lead Tee1,2, Maria Luisa Gorno-Tempini3,4,1
1Global Brain Health Institute.
Current Opinion in Neurology
|January 30, 2019
Summary
Primary progressive aphasia (PPA) research has advanced, improving understanding of its clinical and neuroimaging features. This progress enables targeted speech and language therapy and positions PPA as a model for neurodegenerative disease research.
Area of Science:
- Neuroscience
- Neurology
- Speech and Language Pathology
Background:
- Primary progressive aphasia (PPA) knowledge has grown significantly.
- Clinical, neuroimaging, and neuropathological features of PPA are increasingly understood.
- PPA research facilitates studies on disease pathophysiology and targeted speech and language therapy.
Purpose of the Study:
- To summarize current understanding of PPA.
- To discuss PPA's utility as a model for neurodegenerative disease discovery.
- To highlight advancements in PPA research.
Main Methods:
- Review of current scientific literature on PPA.
- Analysis of clinical presentations and neuroimaging features across PPA variants.
- Integration of traditional mapping with functional connectivity and network topology approaches.
Main Results:
- High compatibility observed between PPA clinical presentations and neuroimaging features.
- Enhanced understanding of speech and language neuroanatomy.
- Development of multidimensional neuroanatomical understanding through advanced methodologies.
- Improved targeting of pharmacological and cognitive therapies for specific PPA subtypes.
Conclusions:
- PPA serves as an optimal model for studying neurodegenerative diseases.
- Advancements facilitate research into brain network vulnerability and neurodevelopmental influences.
- PPA research supports the study of non-pharmacological interventions in neurodegeneration.
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