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Related Concept Videos

Hypoxia01:23

Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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Biological Effects of Radiation02:59

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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Long-term Depression01:05

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:03

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Framing Effects03:26

Framing Effects

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Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
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Regional Terms01:12

Regional Terms

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Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
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Related Experiment Video

Updated: Jan 30, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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[LONG-TERM EFFECTS OF EXPOSURE TO PERINATAL HYPOXIA ON MICROVASCULAR ENDOTHELIUM OF NEOCORTEX IN RATS].

V A Otellin, L I Khozhai, T T Sishko

    Zhurnal Evoliutsionnoi Biokhimii I Fiziologii
    |January 30, 2019
    PubMed
    Summary

    Salifen, a GABA derivative, protects rat neocortex microvasculature endothelium from perinatal hypoxia damage. This neuroprotective effect preserves capillary structure and function, supporting its clinical use.

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    Area of Science:

    • Neuroscience
    • Vascular Biology
    • Developmental Biology

    Background:

    • Perinatal hypoxia can cause long-term damage to the developing brain's microvasculature.
    • The endothelium and other vascular elements are vulnerable to hypoxic injury.
    • GABA derivatives are explored for neuroprotective potential.

    Purpose of the Study:

    • To investigate the protective effects of salifen on the microvasculature of the rat neocortex following perinatal hypoxia.
    • To assess the long-term impact of salifen on endothelial cells, capillary structure, and perivascular elements.

    Main Methods:

    • Administration of salifen, a GABA derivative, at therapeutic doses post-hypoxia.
    • Morphological analysis of microvessel wall elements in rat neocortex.
    • Comparison of vascular structures between control, hypoxia-only, and hypoxia-plus-salifen groups.

    Main Results:

    • Salifen prevented endothelial hypertrophy and the formation of endotheliocyte processes into the vascular lumen.
    • Capillary lumen narrowing and disruptions in lamina densa formation were absent in salifen-treated animals.
    • Perivascular astrocyte swelling and reactive pericyte changes were not observed; vessel density and cross-sectional area remained stable.

    Conclusions:

    • Salifen demonstrates a significant protective effect on the neocortical microvasculature endothelium after perinatal hypoxia.
    • The drug preserves the structural integrity of capillaries and associated cells.
    • These findings support the clinical efficacy of salifen and warrant further investigation into its therapeutic applications.