[Endogenous Cannabinoid System of the Brain as the Target for Influences at Neurodegenerate Diseases]

The review represents the analysis of works about role of endogenous cannabinoid (EC) system in the neuro- degenerate diseases (ND), in which the cellular death and disturbances of neuronal functions of the hippo- campus, neocortex and striatum are observed. Here, the diseases.ofAlzheimer, of Parkinson, of Hangtington, and the temporal lobe epilepsy are considered. Data, on the known or assumed mechanisms of these diseases are provided. In spite of the fact that the etiology.of the listed ND varies, their pathogenesis is characterized by common features: neural hyperexcitability, trophic deprivation, oxidative stress and energy deficite. Cognitive violations and/or deficiency of senso-motor integration are characteristic of patients with ND. Now reliable medicines for treatment of ND are absent. In recent years the fundamental role of EC system in regu- lation of neuroexcitability, energy metabolism, inflammatory and many other processes has been opened in ND pathogenesis. It points to possibility of development of therapeutic approaches which use the prepara- tions for activation of EC system. In the review various mechanisms of cellular survival and their reparations provided to EC system during action of pathological factors are stated.