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[Antigestagens].

J F van Uem1, G D Hodgen

  • 1Klinik für Frauenheilkunde und Poliklinik der Universität Erlangen-Nürnberg.

Geburtshilfe Und Frauenheilkunde
|December 1, 1988
PubMed
Summary
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Disparate actions of mifepristone (RU 486) on glands and stroma in the primate endometrium.

Human reproduction (Oxford, England)·1999

Potent 19-norprogestin derivatives, a breakthrough in steroid endocrinology, show promise for fertility control. These antiprogestins also have potential therapeutic roles in cancer and endometriosis treatment.

Area of Science:

  • Steroid endocrinology
  • Pharmacology
  • Reproductive medicine

Context:

  • Development of novel 19-norprogestin derivatives related to RU 486.
  • These steroids act at the receptor level, representing a significant advancement.

Purpose:

  • To discuss the biochemical, pharmacological, and clinical aspects of these antiprogestins.
  • To explore their potential therapeutic applications.

Summary:

  • Potent 19-norprogestin derivatives have been developed, acting as antiprogestins.
  • Clinical studies suggest their utility in fertility control.
  • Their role in managing endometrial and breast cancers, endometriosis, and labor induction is examined.

Impact:

Keywords:
Abortion, Drug InducedAbortion, InducedBiologyBreast CancerCancerCritiqueDeveloped CountriesDiseasesEndocrine SystemEuropeFamily PlanningFertility Control, PostconceptionGermanyHormone AntagonistsHormonesNeoplasmsPhysiologyRu-486Western Europe

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  • Represents a major breakthrough in steroid endocrinology.
  • Potential applications in reproductive health and oncology.
  • May offer new therapeutic strategies for various medical conditions.