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Updated: Jan 30, 2026

Primary Culture of Neurons Isolated from Embryonic Mouse Cerebellum
Published on: October 26, 2019
SUFU: The Jekyll and Hyde of the Cerebellum
Leo J Y Kim1, Shruti Bhargava2, Ryan C Gimple1
1Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA 92037, USA; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Abstract:
Pediatric tumors have enriched the understanding of germline genotype contribution to tumorigenesis. In this issue of Developmental Cell, Yin et al. (2018) describe genetic models of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SUFU alterations, painting more nuanced roles for SUFU in tumorigenesis and maintenance of Gli2 transcription factor circuitries.
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