Related Experiment Video
Updated: Jan 30, 2026
10:36
Rare Event Detection Using Error-corrected DNA and RNA Sequencing
Published on: August 3, 2018
12.6K
Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET
Yihuan Lu1,2, Jean-Dominique Gallezot1, Mika Naganawa1
1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.
Physics in Medicine and Biology
|January 30, 2019
Summary
Body motion (BM) in positron emission tomography (PET) compromises quantitative accuracy. A new data-driven algorithm, centroid of distribution (COD), effectively detects and corrects for BM, improving image quality and tracer uptake measurements.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Biophysics
Background:
- Positron Emission Tomography (PET) enables absolute in vivo radiotracer quantitation.
- Voluntary body motion (BM) significantly degrades PET image quality, leading to inaccurate tracer uptake measurements and parameter estimations.
- Current body motion correction (BMC) methods, such as frame-based image registration (FIR) and external device tracking, have limitations in clinical practicality and intra-frame motion detection.
Purpose of the Study:
- To introduce a novel, data-driven algorithm, centroid of distribution (COD), for detecting body motion (BM) in PET imaging.
- To evaluate the efficacy of the COD-based BMC approach in improving the accuracy of quantitative PET measurements.
- To compare the performance of the COD-based BMC method against conventional FIR approaches.
Main Methods:
- A data-driven algorithm, centroid of distribution (COD), was developed to detect BM by analyzing abrupt changes in the lateral direction of a COD trace derived from time-of-flight (TOF) bins.
- Body motion was estimated using non-rigid image registrations after detection.
- Correction was performed through list-mode reconstruction.
- The COD-based BMC approach was validated in a monkey study and compared to FIR in human and dog studies using multiple tracers.
Main Results:
- The proposed COD algorithm successfully detected body motion (BM) events during PET scans.
- The COD-based BMC approach demonstrated superior correction results compared to conventional FIR methods.
- The method showed improved accuracy in quantitative measurements and image resolution.
Conclusions:
- The centroid of distribution (COD) algorithm provides an effective and practical solution for detecting and correcting body motion (BM) in PET imaging.
- This novel approach enhances the reliability of quantitative radiotracer uptake measurements, crucial for clinical applications.
- The COD-based BMC method offers a significant advancement over existing techniques, improving the diagnostic value of PET scans.
Related Concept Videos
01:12Equation of Motion for a Rigid Body
628
The movement of a rigid object can be understood through the equations that explain both translational and rotational motion about the center of mass of the object, point G. This center of mass is the point where the equation of motion for translational motion comes into play, as per Newton's Second Law.
The combined moments generated about the center of mass of the object are equal to the rate of change of the angular momentum of the body. An external force, when applied at a different...
The combined moments generated about the center of mass of the object are equal to the rate of change of the angular momentum of the body. An external force, when applied at a different...
628
01:22Planar Rigid-Body Motion
1.0K
Understanding the movement of a rigid body in planar motion involves recognizing that every particle within this body is traversing a path that maintains a consistent distance from a specific plane. This concept is fundamental in the study of physics and mechanical engineering, and it allows us to comprehend better how objects move in space.
Planar motion is typically divided into three distinct categories. The first is rectilinear translation, demonstrated by a subway train that moves along...
Planar motion is typically divided into three distinct categories. The first is rectilinear translation, demonstrated by a subway train that moves along...
1.0K
01:28Integration of Synaptic Events
3.8K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
3.8K
00:49Rigid Body Equilibrium Problems - I
5.5K
A rigid body is said to be in static equilibrium when the net force and the net torque acting on the system is equal to zero. To solve for rigid body equilibrium problems, do the following steps.
5.5K
01:21Rigid Body Equilibrium Problems - II
8.0K
A rigid body is in static equilibrium when the net force and the net torque acting on the system are equal to zero.
Consider two children sitting on a seesaw, which has negligible mass. The first child has a mass (m1) of 26 kg and sits at point A, which is 1.6 meters (r1) from the pivot point B; the second child has a mass (m2) of 32 kg and sits at point C. How far from the pivot point B should the second child sit (r2) to balance the seesaw?
Consider two children sitting on a seesaw, which has negligible mass. The first child has a mass (m1) of 26 kg and sits at point A, which is 1.6 meters (r1) from the pivot point B; the second child has a mass (m2) of 32 kg and sits at point C. How far from the pivot point B should the second child sit (r2) to balance the seesaw?
8.0K
01:21Schwarzschild Radius and Event Horizon
2.7K
No object with a finite mass can travel faster than the speed of light in a vacuum. This fact has an interesting consequence in the domain of extremely high gravitational fields.
The minimum speed required to launch a projectile from the surface of an object to which it is gravitationally bound so that it eventually escapes the object’s gravitational field is called the escape velocity. The escape velocity is independent of the mass of the object. Merging the idea of escape...
The minimum speed required to launch a projectile from the surface of an object to which it is gravitationally bound so that it eventually escapes the object’s gravitational field is called the escape velocity. The escape velocity is independent of the mass of the object. Merging the idea of escape...
2.7K