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Effect of Verapamil on Kidney Function Using Radionuclide Imaging.

Seham Mustafa1, Abdelhamid H Elgazzar2, Nabil Kamal3

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Pharmacology
|January 30, 2019
PubMed
Summary
This summary is machine-generated.

Verapamil, a calcium channel blocker, dilates renal arteries and improves kidney blood flow and function. However, it can alter renogram results, so it should not be used during these kidney function tests.

Keywords:
Calcium channel blockersRenogramTechnetium-99m mercaptoacetyltriglycineVerapamil

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Area of Science:

  • Pharmacology
  • Nephrology
  • Cardiovascular Medicine

Background:

  • Calcium channel blockers (CCBs) are widely prescribed for cardiovascular diseases.
  • Verapamil is a commonly used CCB.
  • The impact of verapamil on kidney function requires investigation.

Purpose of the Study:

  • To investigate the effect of verapamil on kidney function.
  • To assess verapamil's impact using radionuclide imaging and renography.

Main Methods:

  • In vitro studies on isolated rabbit renal artery segments.
  • In vivo renographic studies in rabbits using Technetium-99m mercaptoacetyltriglycine.
  • Analysis of time to peak activity (Tmax) and T1/2 from renograms.

Main Results:

  • Verapamil reduced phenylephrine-induced contraction in renal arteries by 30%.
  • In vivo, verapamil significantly decreased Tmax and T1/2 in renograms (p < 0.05).
  • These changes indicate enhanced renal uptake and clearance of the tracer.

Conclusions:

  • Verapamil dilates renal arteries, accelerating renogram parameters.
  • It improves renal blood perfusion and kidney function.
  • Verapamil interferes with renogram results and should be avoided during testing.