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Postnatal Paraclinical Parameters Associated to Occurrence of Intracerebral Hemorrhage in Preterm Infants

Renée Lampe1,2, Varvara Turova1, Nikolai Botkin3

  • 1Research Unit for Paediatric Neuroorthopaedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Orthopedic Department, University Hospital "rechts der Isar," Technical University of Munich, Munich, Germany.

Neuropediatrics
|January 30, 2019
PubMed

Insights

Lower hematocrit, SaO2, and pH levels are significant indicators of intracerebral hemorrhage (ICH) in preterm infants. Elevated C-reactive protein and lower thrombocyte counts also correlate with ICH development in specific gestational age groups.

Area of Science:

  • Neonatal Medicine
  • Pediatric Neurology
  • Clinical Biochemistry

Background:

  • Intracerebral hemorrhage (ICH) is a common complication in preterm infants.
  • Early identification of risk factors is crucial for managing ICH in this vulnerable population.

Purpose of the Study:

  • To statistically evaluate seven standard paraclinical parameters for their association with ICH development in preterm infants.
  • To identify specific paraclinical indicators that may predict ICH risk.

Main Methods:

  • Analysis of clinical records from 265 preterm infants (gestational age 23-30 weeks).
  • Comparison of paraclinical parameters between infants with and without ICH, considering different ICH grades and time periods.
  • Statistical evaluation of hematocrit, SaO2, pH, C-reactive protein, and thrombocyte counts.

Main Results:

  • Lower hematocrit, SaO2, and pH were statistically significant indicators of ICH in preterm infants (23-30 weeks GA).
  • Higher C-reactive protein and lower thrombocyte values were associated with ICH in infants aged 27-30 weeks GA.
  • Infants aged 23-26 weeks GA showed similar C-reactive protein levels but lower thrombocyte counts post-bleeding compared to controls.

Conclusions:

  • Paraclinical parameters like hematocrit, SaO2, pH, C-reactive protein, and thrombocyte counts can serve as valuable indicators for ICH risk in preterm infants.
  • These findings support closer clinical observation of preterm infants identified as high-risk for ICH based on specific paraclinical values.

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