Related Experiment Video
Updated: Jan 30, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
Published on: January 15, 2013
Miniature all-fiber axicon probe with extended Bessel focus for optical coherence tomography
Abstract:
The trade-off between lateral resolution and depth of focus (DOF) severely limits the capability of endoscopic optical coherence tomography (OCT) for high-resolution deep-tissue imaging. To address this issue, we developed a novel miniature all-fiber axicon OCT probe by inserting a segment of gradient-index (GRIN) fiber between a piece of single-mode fiber (SMF) and an axicon polished from a no-core fiber. The GRIN lens served as a beam expander extending the probe DOF by 5.2 times while maintaining a high lateral resolution of 2 μm. The DOF extension was experimentally verified by measuring the axial profile of the probe output beam and further by imaging multilayered polymer tapes and onion samples. The designed probe with a tight focus over a large DOF holds great potential in endoscopic OCT imaging of deep tissues at the cellular level.
Related Concept Videos
Classification of Skeletal Muscle Fibers
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Gravitational Potential Energy for Extended Objects
Focusing of Light in the Eye
Coping Strategies: Problem Focused
For example, consider a student who struggles to understand their...
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Coping Strategies: Emotion Focused

