Related Experiment Video

Updated: Jan 30, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
06:45

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

874

Efficacy of Prophylactic Negative Pressure Wound Therapy After Pediatric Liver Transplant

Genshiro Esumi1, Toshiharu Matsuura, Makoto Hayashida

  • 1From the Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|January 31, 2019
PubMed

Insights

Negative pressure wound therapy effectively prevents surgical site complications in pediatric liver transplant patients. This approach significantly reduced wound dehiscence compared to conventional methods.

Area of Science:

  • Surgical complications
  • Transplantation
  • Wound healing

Background:

  • Wound dehiscence is a frequent surgical complication in pediatric liver transplant recipients.
  • Negative pressure wound therapy (NPWT) was implemented in 2013 to prevent such complications.

Purpose of the Study:

  • To evaluate the clinical outcomes of prophylactic NPWT in pediatric liver transplant recipients.
  • To compare the incidence of surgical complications between conventional wound management and NPWT.

Main Methods:

  • Retrospective review of 25 pediatric liver transplant recipients.
  • Patients were divided into a conventional wound management group (n=13) and a prophylactic NPWT group (n=12).
  • Comparison of surgical complication rates and patient characteristics between the two groups.

Main Results:

  • Wound dehiscence occurred in 7/13 patients (conventional group) vs. 3/12 patients (prophylactic group).
  • Surgical debridement for dehiscence was required in 6/13 patients (conventional group) vs. 0/12 patients (prophylactic group).
  • The prophylactic NPWT group showed a significantly lower incidence of wound dehiscence (P = .015), despite having more severe liver insufficiency.

Conclusions:

  • Prophylactic negative pressure wound therapy is effective in preventing wound dehiscence in pediatric liver transplant recipients.
  • NPWT offers a promising strategy to reduce surgical site complications in this vulnerable patient population.
Abstract

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