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Published on: January 29, 2020
Incidence and prevalence of vitreomacular traction with and without macular hole in Germany
Jacob Menzler1, Aljoscha Steffen Neubauer1,2, Christos Haritoglou3
1Institute for Health- and Pharmacoeconomics/Neubauer Consult, Munich, Germany, jacob.menzler@ifgph-muenchen.de.
Purpose:
Symptomatic vitreomacular adhesion (sVMA) comprises vitreomacular traction (VMT) and stage 1 and 2 full-thickness macular holes (MHs) associated with vitreomacular adhesion (VMA). We aimed to estimate the incidence and prevalence of sVMA in Germany.
Materials And Methods:
A systematic literature review was conducted to identify the incidence and prevalence of sVMA based on international epidemiologic studies, weighted for study size and then averaged across eligible studies. A second systematic review aimed to estimate the proportion of vitrectomy undertaken for sVMA in Germany. This was combined with the reported number of vitrectomies in Germany in 2016 to estimate the number of patients undergoing vitrectomy for sVMA.
Results:
The prevalence of sVMA is 1,365 per 100,000 population, with an incidence of 6.96 per 100,000 per year. For Germany, this translates to 1,119,300 cases, with 5,700 new cases reported annually. Analyzing the national hospital statistics, ~2,300 patients undergo vitrectomy due to sVMA in Germany each year, of which about 1,700 patients have VMT.
Conclusion:
Incidence figures, driven by patients presenting to clinic, are much lower than expected based on population-based studies, suggesting that many patients with sVMA exist outside of the clinic system.
Insights
Symptomatic vitreomacular adhesion (sVMA) affects over 1.1 million people in Germany, with an annual incidence of 5,700 new cases. Many sVMA patients remain undiagnosed outside clinical settings.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Public Health
Background:
- Symptomatic vitreomacular adhesion (sVMA) includes vitreomacular traction (VMT) and macular holes (MHs).
- Understanding the epidemiology of sVMA is crucial for healthcare planning.
Purpose of the Study:
- To estimate the incidence and prevalence of sVMA in Germany.
- To determine the number of vitrectomies performed for sVMA in Germany.
Main Methods:
- Systematic literature review of international epidemiologic studies for sVMA incidence and prevalence.
- Second systematic review to estimate the proportion of vitrectomies for sVMA in Germany.
- Combined review data with national vitrectomy statistics for 2016.
Main Results:
- Estimated sVMA prevalence: 1,365 per 100,000 population (1,119,300 cases in Germany).
- Estimated sVMA incidence: 6.96 per 100,000 per year (5,700 new cases annually in Germany).
- Approximately 2,300 vitrectomies performed annually for sVMA in Germany; ~1,700 for VMT.
Conclusions:
- Population-based incidence is lower than expected from clinical data.
- Suggests a significant number of sVMA patients are not currently within the healthcare system.
- Highlights potential underdiagnosis and undertreatment of sVMA.
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