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Frequency-dependent neural activity in primary angle-closure glaucoma.

Fei Jiang1, Chen Yu2, Min-Jing Zuo1

  • 1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.

Neuropsychiatric Disease and Treatment
|January 31, 2019
PubMed
Summary
This summary is machine-generated.

Primary angle-closure glaucoma (PACG) patients show altered spontaneous neural activity in visual and sensorimotor areas. These brain changes may explain vision, cognition, and emotion impairments in PACG.

Keywords:
amplitude of low-frequency fluctuationsfrequency dependentprimary angle-closure glaucomaresting-state magnetic resonance imaging

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • Primary angle-closure glaucoma (PACG) is a significant cause of vision loss.
  • Understanding the neural mechanisms underlying PACG is crucial for effective management.

Purpose of the Study:

  • To investigate frequency-dependent spontaneous neural activity in PACG using Amplitude of Low-Frequency Fluctuations (ALFF).
  • To identify brain regions with altered neural activity in PACG patients compared to controls.

Main Methods:

  • Resting-state fMRI scans were acquired from 52 PACG patients and 52 normal-sighted controls.
  • Repeated-measures ANOVA and t-tests analyzed ALFF in slow-4 and slow-5 frequency bands.
  • Pearson's correlation examined the relationship between ALFF and clinical variables in PACG.

Main Results:

  • PACG patients exhibited distinct ALFF patterns in visual and sensorimotor cortices across frequency bands.
  • Abnormal ALFF in posterior cingulate gyrus and precuneus was more pronounced in the slow-4 band.
  • ALFF in frontal lobe, fusiform, and cerebellum was higher in the slow-5 band.
  • Increased ALFF in the right inferior occipital gyrus correlated with thinner retinal nerve fiber layer and larger visual fields.

Conclusions:

  • PACG is associated with abnormal spontaneous neural activity in visual, sensorimotor, and default mode networks.
  • These neural alterations may contribute to impaired vision, cognition, and emotion in PACG.
  • Findings provide insights into the neural underpinnings of PACG.