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IgG4-related disease in endocrine practice
Agata Rzepecka1, Anna Babińska1, Krzysztof Sworczak1
1Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
Archives of Medical Science : AMS
|January 31, 2019
Summary
Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition affecting multiple organs. This summary highlights its diverse manifestations and the under-recognized link to endocrine disorders.
Area of Science:
- Endocrinology
- Rheumatology
- Pathology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition affecting various organs, characterized by lymphoplasmacytic infiltrations, fibrosis, and elevated serum IgG4 levels.
- The disease presents with diverse clinical manifestations and multifactorial etiopathogenesis, with nearly forty reported locations, including the endocrine system.
- IgG4-related endocrinopathies are rare but likely under-diagnosed due to limited awareness.
Purpose of the Study:
- To review the current understanding of IgG4-related disease (IgG4-RD) and its impact on the endocrine system.
- To emphasize the diagnostic challenges and the need for increased awareness of IgG4-related endocrinopathies.
- To highlight the paucity of robust studies investigating the association between IgG4-RD and endocrine disorders.
Main Methods:
- Review of existing literature on IgG4-related disease and endocrine manifestations.
- Analysis of diagnostic criteria, including clinical history, physical examination, and histopathology.
- Synthesis of reported cases and epidemiological data concerning IgG4-related endocrinopathies.
Main Results:
- IgG4-RD can affect various endocrine glands, leading to diverse hormonal dysfunctions.
- Diagnosis relies on a combination of clinical, serological (elevated IgG4), and histopathological findings.
- Despite its rarity, IgG4-related endocrinopathies represent a significant diagnostic challenge.
Conclusions:
- IgG4-related disease encompasses a wide range of organ involvements, including the endocrine system.
- Increased clinical suspicion and awareness are crucial for diagnosing under-reported IgG4-related endocrinopathies.
- Further research is needed to elucidate the precise relationship between IgG4-RD and endocrine disorders.
Keywords:
Graves’ ophthalmopathyHashimoto’s thyroiditisIgG4-related diseaseRiedel’s thyroiditishypophysitisMore Related Videos
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