Related Experiment Video

Updated: Jan 30, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
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A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

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Prediction of mortality in patients with implantable defibrillator using CHADS2 score: data from a prospective

Giovanni Morani1, Domenico Facchin2, Giulio Molon3

  • 1Division of Cardiology, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, University of Verona Verona, Italy.

American Journal of Cardiovascular Disease
|January 31, 2019
PubMed

Insights

The CHADS2 score effectively predicts mortality risk in patients with implantable cardioverter defibrillators, regardless of atrial fibrillation history. Higher CHADS2 scores indicate increased risk of all-cause mortality.

Area of Science:

  • Cardiology
  • Clinical Risk Stratification
  • Public Health

Background:

  • The CHADS2 score is validated for predicting stroke risk in atrial fibrillation (AF) patients.
  • This study investigates the CHADS2 score's utility in predicting all-cause mortality.
  • Patient risk factors, particularly the CHADS2 score, are assessed for mortality risk identification.

Purpose of the Study:

  • To evaluate the CHADS2 score as a predictor of all-cause mortality.
  • To assess the association between CHADS2 score-defined risk categories and long-term mortality.
  • To determine if CHADS2 score predicts mortality independently of AF history.

Main Methods:

  • Prospective follow-up of 821 patients with implantable cardioverter defibrillators across 11 centers.
  • Patients categorized into low (CHADS2=0), moderate (CHADS2=1-2), and high (CHADS2=3-6) risk groups.
  • Mortality data collected via medical records and vital statistics, with survival analysis performed.

Main Results:

  • A total of 135 deaths occurred over a mean follow-up of 44 months.
  • Mortality rates were significantly higher in high-risk (24.6%) compared to moderate (13.8%) and low-risk (7.7%) groups.
  • High CHADS2 score was an independent predictor of mortality (HR 1.88, P=0.002), even in patients without AF history.

Conclusions:

  • The CHADS2 score is a valuable tool for predicting all-cause mortality in patients with implantable cardioverter defibrillators.
  • Long-term mortality risk increases with higher CHADS2 scores, irrespective of atrial fibrillation presence.
  • The CHADS2 score aids in identifying high-risk individuals for mortality, supporting its clinical utility.
Abstract

Keywords:
CHADS2 scoreImplantable cardioverter defibrillatorall cause mortalityatrial fibrillationprediction of mortality

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