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Related Experiment Video

Updated: Jan 30, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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GenoDup Pipeline: a tool to detect genome duplication using the dS-based method.

Yafei Mao1

  • 1Marine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, Japan.

Peerj
|January 31, 2019
PubMed
Summary
This summary is machine-generated.

Whole genome duplication (WGD) is key to organismal evolution. A new pipeline, GenoDup, accurately detects WGD from next-generation sequencing data in plants and animals.

Keywords:
Age distributionGenoDupNext generation sequencing (NGS)PolyploidySoftwareWhole-genome duplication (WGD)dS-based

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Area of Science:

  • Evolutionary Biology
  • Genomics
  • Bioinformatics

Background:

  • Whole genome duplication (WGD), also known as polyploidy, is a significant evolutionary mechanism driving organismal diversification.
  • The rapid advancement of next-generation sequencing (NGS) technologies has generated vast amounts of genomic data, necessitating efficient WGD detection tools.

Purpose of the Study:

  • To develop and present a user-friendly and accurate computational pipeline for inferring whole genome duplication (WGD) from NGS data.
  • To provide a reliable tool for evolutionary biologists and researchers studying genome evolution.

Main Methods:

  • Development of the GenoDup pipeline, a user-friendly tool for WGD inference.
  • Utilizing a dS-based method for detecting WGD events.
  • Application of the GenoDup pipeline to empirical genomic datasets from both plant and animal species.

Main Results:

  • The GenoDup pipeline was successfully developed and validated.
  • GenoDup effectively identified WGD events in diverse empirical datasets.
  • The pipeline demonstrated accuracy and user-friendliness in WGD detection.

Conclusions:

  • The GenoDup pipeline offers a reliable and practical solution for inferring WGD from NGS data.
  • This tool aids in understanding the role of WGD in the origin and diversification of species.
  • GenoDup is a valuable asset for genomic research in evolutionary biology.