Gene variants of adhesion molecules predispose to MS: A case-control study
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Updated: Jan 30, 2026
Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
Published on: June 29, 2016
Efthimios Dardiotis1, Elena Panayiotou1, Vasileios Siokas1
1Cyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Objective:
To examine the effect of variants in genes encoding molecules that are implicated in leukocyte trafficking into the CNS on the development of MS.
Methods:
A total of 389 Greek MS cases and 336 controls were recruited by 3 MS centers in Cyprus and Greece. In total, 147 tagging single nucleotide polymorphisms across 9 genes encoding for P-selectin (SELP), integrins (ITGA4, ITGB1, and ITGB7), adhesion molecules (ICAM1, VCAM1, and MADCAM1), fibronectin 1 (FN1), and osteopontin (SPP1) were genotyped. The clinical end point of the study was diagnosis of MS according to the 2005 revised McDonald criteria. Permutation analysis was used for adjusting for multiple comparisons.
Results:
Overall, 21 variants across SELP, ITGA4, ITGB1, ICAM1, VCAM1, MADCAM1, FN1, and SSP1 genes were each associated with MS (p perm < 0.05). The most significant were rs3917779 and rs2076074 (SELP), rs6721763 (ITGA4), and rs1250258 (FN1), all with a permutation p value of less than 1e-004.
Conclusions:
The current study provides preliminary evidence that variants across genes encoding adhesion molecules, responsible for lymphocyte adhesion and trafficking within the CNS, are implicated in the risk of developing MS.
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