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Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

68.1K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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What is the Endocrine System?00:46

What is the Endocrine System?

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The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
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The Endocrine System01:29

The Endocrine System

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The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
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An Overview of the Endocrine System01:10

An Overview of the Endocrine System

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The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
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Structures of the Endocrine System00:59

Structures of the Endocrine System

12.1K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
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Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
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Related Experiment Video

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Murine Model of Epicutaneously-Induced Immunomodulation
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Exploring immunomodulation by endocrine changes in Lady Windermere syndrome.

M R Holt1,2, J J Miles3, W J Inder1,4

  • 1Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Clinical and Experimental Immunology
|January 31, 2019
PubMed
Summary
This summary is machine-generated.

Postmenopausal women with Lady Windermere syndrome have increased risk for nontuberculous mycobacteria (NTM) lung disease. Endocrine changes, like oestrogen deficiency, may influence susceptibility to NTM infections.

Keywords:
adipokineshormonesimmune responsenontuberculous mycobacteriaoestrogen

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Area of Science:

  • Pulmonology
  • Endocrinology
  • Immunology

Background:

  • Nontuberculous mycobacteria (NTM) lung disease disproportionately affects postmenopausal women with Lady Windermere syndrome, characterized by low BMI, tall stature, and specific physical traits.
  • The exact cause of susceptibility in these women is unknown but likely involves multiple factors, including hormonal changes and altered adipokine production.
  • Previous studies show altered adipokine and dehydroepiandrosterone levels in NTM lung disease patients, and hypopituitarism cases suggest a link between endocrine function and disease risk.

Purpose of the Study:

  • To review evidence linking endocrine changes to immune responses in Lady Windermere syndrome.
  • To explore the potential role of hormonal factors in susceptibility to NTM lung disease in this patient group.

Main Methods:

  • Literature review focusing on immunomodulatory effects of endocrine changes relevant to Lady Windermere syndrome.
  • Analysis of existing data on adipokines, dehydroepiandrosterone, and hypopituitarism in NTM lung disease.

Main Results:

  • Oestrogen deficiency and altered adipokine profiles are potential contributors to NTM lung disease susceptibility.
  • Evidence suggests that endocrine dysfunction may play a role in the immune response to NTM.

Conclusions:

  • The findings support further investigation into the endocrine system's role in NTM lung disease susceptibility in women with Lady Windermere syndrome.
  • An endocrine link to disease susceptibility warrants deeper exploration in this unique patient population.