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Leptin rs2167270 G > A (G19A) polymorphism may decrease the risk of cancer: A case-control study and meta-analysis
Jing Yang1, Zhihui Zhong2, Weifeng Tang3
1Department of Gastroenterology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Journal of Cellular Biochemistry
|January 31, 2019
Summary
The LEP G19A variant is linked to a reduced risk of overall cancer. This genetic variation may decrease susceptibility to specific cancers like non-Hodgkin lymphoma and colorectal cancer.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Leptin (LEP) plays a significant role in cancer development.
- Previous studies on the LEP G19A variant and cancer risk have produced conflicting results.
Purpose of the Study:
- To investigate the association between the LEP G19A polymorphism and cancer risk in a Chinese population.
- To perform a meta-analysis of existing studies to clarify the overall association between the LEP G19A locus and cancer susceptibility.
Main Methods:
- A case-control study was conducted with 1063 esophagogastric junction adenocarcinoma cases and 1677 controls.
- A pooled analysis included 13 studies with 8059 cancer patients and 11930 controls.
- Statistical analysis using odds ratios (ORs) and 95% confidence intervals (CIs) evaluated the associations.
Main Results:
- The study found an association between LEP 19A allele carriers and an increased risk of EGJA in the Chinese population.
- Meta-analysis revealed significant associations between the LEP G19A polymorphism and reduced overall cancer risk.
- Stratified analyses indicated that the LEP 19A allele may decrease susceptibility to non-Hodgkin lymphoma and colorectal cancer across various ethnicities.
Conclusions:
- The LEP G19A polymorphism is associated with a decreased risk of overall cancer.
- This genetic variant may play a protective role against certain types of cancer, including NHL and CRC.
- Further research is warranted to fully elucidate the mechanisms underlying the LEP G19A variant's influence on cancer development.
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