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Ristretto MRE: A generalized multi-shot GRE-MRE sequence.

Christian Guenthner1, Sweta Sethi2, Marian Troelstra3,4

  • 1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.

NMR in Biomedicine
|January 31, 2019
PubMed
Summary
This summary is machine-generated.

A new Ristretto scheme for MR elastography (MRE) significantly reduces scan times by allowing flexible timing of imaging sequences. This method accelerates conventional GRE-MRE by 2- to 4.5-fold without affecting displacement or stiffness accuracy.

Keywords:
GRE-MREMR elastographyeXpressointerleaved acquisitionmulti-shotmulti-slice

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Magnetic Resonance Imaging

Background:

  • Conventional gradient-recalled echo MR elastography (GRE-MRE) requires synchronization between MRI sequences and wave periods for consistent k-space data.
  • Low wave frequencies (<100 Hz) in GRE-MRE lead to prolonged acquisition times due to the inverse relationship between repetition time and frequency.
  • Existing multi-shot methods like eXpresso MRE offer acceleration but impose restrictive constraints.

Purpose of the Study:

  • To generalize the eXpresso MRE sequence by introducing sequence delays and interleaved wave-phase acquisition.
  • To develop the Ristretto scheme for faster and more flexible GRE-MRE acquisitions.
  • To compare the Ristretto scheme against conventional GRE-MRE and eXpresso MRE in terms of scan duration and accuracy.

Main Methods:

  • Proposed a three-step generalization of the GRE-MRE sequence, incorporating sequence delays and interleaved wave-phase acquisition (Ristretto scheme).
  • Validated the Ristretto scheme through phantom studies, assessing displacement fields, performance at various actuation frequencies (25-60 Hz), and acquisition of different slice numbers (13-17).
  • Demonstrated in vivo feasibility in liver and breast, comparing Ristretto with an optimized eXpresso sequence.

Main Results:

  • The Ristretto scheme allows imaging shot durations to be selected independently of slice number and wave frequency.
  • Phantom studies showed agreement in displacement fields across sequence generalization stages.
  • In vivo studies demonstrated scan accelerations of 15% (liver) and 5% (breast) with Ristretto compared to optimized eXpresso, without compromising accuracy.

Conclusions:

  • The Ristretto scheme overcomes the restrictive constraints of previous methods, enabling significant acceleration of GRE-MRE.
  • This generalized approach permits 2- to 4.5-fold acceleration of conventional GRE-MRE acquisitions.
  • Ristretto offers a flexible and efficient alternative for MRE, maintaining diagnostic accuracy.