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A Single-Atom Nanozyme for Wound Disinfection Applications
Bolong Xu1, Hui Wang2, Weiwei Wang1
1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
Angewandte Chemie (International Ed. in English)
|January 31, 2019
Summary
This study introduces a zinc-based single-atom nanozyme derived from ZIF-8 as an efficient peroxidase mimic for wound antibacterial applications. This novel nanozyme demonstrates high therapeutic effects and biosafety, paving the way for advanced wound care solutions.
Area of Science:
- Catalysis
- Materials Science
- Biotechnology
Background:
- Single-atom catalysts (SACs) are extensively studied for chemical catalysis.
- Applications of SACs in enzymatic catalysis remain underexplored.
- Zeolitic-imidazolate-framework (ZIF-8) derived materials offer unique structural properties.
Purpose of the Study:
- To develop and characterize a novel single-atom nanozyme (SAzyme) for enzymatic catalysis.
- To investigate the structure-activity relationship of the SAzyme.
- To explore the potential of the SAzyme in wound antibacterial applications.
Main Methods:
- Synthesis of a zinc-based ZIF-8 derived carbon nanomaterial with atomically dispersed zinc.
- Systematic investigation of the structural evolution of the SAzyme.
- Density functional theory (DFT) calculations to elucidate active sites and catalytic mechanisms.
Main Results:
- The developed SAzyme functions as a highly efficient single-atom peroxidase mimic.
- Coordinatively unsaturated active zinc sites were identified as crucial for catalytic activity.
- The SAzyme demonstrated significant therapeutic effects and excellent biosafety.
Conclusions:
- The zinc-based SAzyme derived from ZIF-8 shows great promise as a peroxidase mimic.
- The study provides insights into the structure-activity relationship and catalytic mechanism of SAzymes.
- The SAzyme exhibits potential for effective and safe wound antibacterial applications.
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