Related Experiment Videos
Monocytes and impaired leukocyte migration inhibitory factor production in head and neck squamous carcinoma
1Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor.
Head & Neck Surgery
|January 1, 1988
Abstract:
Impaired cell-mediated immunity has been consistently associated with head and neck squamous carcinoma (HNSC). Previous work has implicated monocytes in this impairment. The present study shows that in a subgroup of untreated patients with advanced HNSC, monocytes are responsible for impaired in vitro lymphokine (leukocyte migration inhibitory factor) production. In view of recent studies suggesting interactions between lymphokines and monocytes in the immune response, the present findings may be relevant to future immunotherapeutic approaches.